AlloAid Amniotic Liquid Allograft

A cryopreserved allograft derived from human amniotic fluid.

Amniotic fluid is a versatile, powerful tissue which supports the development of the fetus in utero. The properties of amniotic fluid which benefit the fetus also make it an effective material for covering wounds1-3,7, while at the same time contributing to an environment conducive to the regeneration of healthy tissue.4-7

Allogenic human birth tissues, including amniotic fluid, have an established record of use in a variety of surgical and clinical settings. Published literature suggests that amniotic fluid may contain important growth factors1,2,6, extracellular matrix2,5,6 molecules, hyaluronic acid1,4-6, fibronectin2, laminin4, prostaglandins3, and cells.7

Benefits of amniotic fluid may include:
  • A safe, natural covering for wounds1,7
  • Inhibiting influence on inflammation3
  • Reduced fibrosis, scarring, and adhesion at the surgical site4

Intended for topical application as a covering over wounds or areas of localized inflammation. Birth tissues are recovered during planned Cesarean sections and processed aseptically in a manner to preserve the graft’s inherent properties. Though well documented in the clinical literature, these benefits of amnion have not been studied using AlloAid Amniotic Liquid Allograft products.

Handling & Storage Guidelines

  • Store at -70°C or colder. Thaw only prior to use.
  • Allow product to thaw by standing at room temperature and apply directly to the injury, wound, or area of inflammation.
  • See instructions for use for a more detailed description.

Tissue Safety

  • Placental donors go through a rigorous pre- screening qualification and are tested according to FDA guidelines for infectious disease.
  • Collection of the donor tissue is performed during planned Cesarean section delivery by appropriately licensed personnel.
  • Processed in accordance with the standards and guidelines established by the American Association of Tissue Banks (AATB).

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Ordering Information

References – 1. Nyman E, Huss F, Nyman T, Junker J, Kratz G. (2013 Apr) Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: in vitro studies of re-epithelialisation in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92 2. Adzick NS, Lorenz HP. (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery.;220(1):10-18.3. Gao X, Devoe LD, Given KS. (1994 Aug) Effects of amniotic fluid on proteases: a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 33(2):128-134; discussion 134-135. 4. Bolat E, Kocamaz E, Kulahcilar Z, Yilmaz A, Topcu A, Ozdemir M, Coskun ME. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4):253-9. 5. Cobanglu U, Kutlu N, Karacal N, Kosucu P. (2005 Dec) Effect of human amniotic fluid on bone healing. J Surg Res. 129(2):283-7. 6. Ozgenel GY, Filiz G, Ozcan M. (2004 Jul) Effects of human amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5):423-8. 7. Rosner M, Hipany K, Shanmugasundaram B, Lubec G, Hengstschläger M (2012 Jun) Amniotic Fluid Stem Cells: Future Perspectives. Stem Cells Int. 2012: 741810.

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