Synergistic Combination of Bioactive Glass and Demineralized Bone Matrix.

BioV^® Bioactive Matrix is a novel bone graft substitute expressly designed to optimize surgical handling, graft stability and osteoproductivity.

Bioactive Glass

Bioactive Glass is an osteoconductive and osteopromotive material that guides new bone formation.

Forms an exceedingly strong interfacial bond between the graft and adjacent bony tissue within minutes¹
Triggers the mechanisms that cause differentiation and proliferation of osteoblasts²
Boosts the activity of critical growth factors needed for bone formation³
Accelerates the process of osteogenesis⁴
Additionally, in vitro studies demonstrate that ionic release (Ca++) and local pH changes inherent to bioactive glass create an unfavorable environment for growth of certain microbes⁵. Bioactive Glass characteristics are based on in vivo and animal data

Demineralized allograft bone

Demineralized allograft bone is an osteoconductive scaffold with osteoinductive potential to facilitate new bone formation

Each lot of DBM is evaluated for osteoinductive (OI) potential using an in vivo athymic rat model
Processed to achieve a sterility assurance level (SAL) of 10^-6
Surface roughness of DBM particles allow for the migration and proliferation of osteogenic cells⁷
Demineralization process exposes natural morphogenic proteins in the bone matrix, making them available for osteogenesis⁸

Performance

A novel and patented process that integrates the osteoinductive and osteoconductive elements of the product

Rapidly reconstitutes and is easily prepared
Product is moldable, extrudable and can be packed into osseous defects
Resists migration during irrigation, allowing the active components to stay in place

Ordering Information

Surgical Technique:

1. Fill the transfer syringe with sterile fluid.

2. Attach the transfer syringe to the female luer port on the product syringe and hold the assembly vertically with the product syringe on top. Inject the sterile fluid into the product syringe.

3. Once the fluid is transferred, compress the plunger of the product syringe until all of the air is removed and the powder is wetted. Wait 2 minutes for the fluid to be completely absorbed into the powder.

4. Remove the fluid transfer syringe and the valve from the product syringe.

5. Extrude the product directly into bony voids or gaps, or into moist gloves.

6. Mold and handle putty as desired. Bio V Bioactive Matrix handles best when used within 12 minutes of reconstitution.

CAUTION: Federal law (USA) restricts this device to sale and use by, or on the order of a physician.

References: 1. Oonishi H, Kushitani S, Yasukawa E, Iwaki H, Hench LL, Wilson J, Tsuji E, Sugihara T (1997) Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop Relat Res 334:316–325 2. Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141. 3. Mulliken JB, Glowacki J, Kaban LB, Folkman J, Murray JE (1981) Use of demineralized allogeneic bone implants for the correction of maxillocraniofacial deformities. Ann Surg 194(3):366–372 4. Mulliken JB, Kaban LB, Glowacki J (1984) Induced osteogenesis—the biological principle and clinical applications. J Surg Res 37(6):487–496 5. Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141. 6. BervenS, TayBK, KleinstueckFS, Bradford DS(2001)Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation. Eur Spine J 10(Suppl 2):S169–S177. doi:10.1007/s005860100270 7. Kirk T. J, (2012) Osteoconductivity and osteoinductivity of Bio V DBM. Cell Tissue Bank DOI 10.1007/s10561-012-9297-1 8. Mulliken JB, Kaban LB, Glowacki J (1984) Induced osteogenesis—the biological principle and clinical applications. J Surg Res 37(6):487–496 9. Kirk T. J, (2012) Osteoconductivity and osteoinductivity of Bio V DBM. Cell Tissue Bank DOI 10.1007/s10561-012-9297-1.

All content contained herein is furnished for informational purposes only. In2Bones does not recommend a particular surgical product or procedure suitable for all patients. Each surgeon must evaluate the appropriateness of a device and corresponding techniques based on medical training, clinical judgment and surgical experience. The proper surgical technique and/or procedure are the responsibility of the medical professional. Indications, contraindications, warnings and precautions are listed in the implant package insert and should be reviewed carefully by the physician and operating room personnel prior to any proposed procedure. Availability of these products might vary from one given country or region to another as a result of specific local regulatory approval or clearance requirements for sale in such country or region.